Acinic cell carcinoma cytology

Pathology Outlines - Acinic cell carcinom

  1. Cytologic diagnosis based on identifying acinar-like cells Tend to form small groups and loosely cohesive clusters as well as single cells (Diagn Histopath 2018;24:417) Cells are large but morphologically resemble normal acinar cells Round nuclei with tiny nucleol
  2. antly found in parotid gland and rarely in submandibular gland or
  3. Definition Acinic cell carcinoma (AcCC) is one of the three most common primary salivary malignancies with adenoid cystic carcinoma and mucoepidermoid carcinoma (Barnes et al. 2005; Ellis 2008). AcCC is an adenocarcinoma showing acinic cell differentiation with zymogen-type secretory granules
  4. Due to the heterogeneous nature of most SG neoplasms, cytologic interpretation on FNA can be quite challenging. This is particularly valid when dealing with rare tumor types, such as the papillary-cystic variant of acinic-cell carcinoma (ACC-PCV), resulting in a high rate of false-negative cytologic diagnoses
  5. Fine-needle aspiration (FNA) cytology is commonly used to evaluate salivary gland lesions and is considered to be highly accurate in the diagnosis of salivary gland tumors. Acinic cell carcinoma is an uncommon malignant neoplasm, mostly arising in the parotid gland. Aspirates from these tumors can be diagnostically challenging
  6. Acinic cell carcinoma Acinic cell carcinoma occurs most frequently in the parotid gland. The former name was 'acinic cell tumor' because in some cases only very mild atypia is present. 2 - 7% of all salivary gland tumors belong to this group. There are four patterns: solid, microcystic, papillary-cystic, follicular
  7. ance with the age of patients ranging from 14 to 79 years.3On histology, various morphologic patterns have been described including solid, microcystic, follicular, and papillary-cystic.

Cytology description Small to moderate sized loose groups with numerous single cells, prominent acinar formation, little anisonucleosis and prominent nucleoli Background cleaner than ductal carcinoma Significant overlap with features of pancreatic endocrine tumors (Diagn Cytopathol 2006;34:367 Uncommon malignant epithelial neoplasm with serous acinar cell differentiation (cytoplasmic zymogen granules) and salivary ductal cell component (J Oral Maxillofac Surg 2010;68:2489) Tumors arise from neoplastic transformation of terminal duct cells (intercalated duct cells) with differentiation toward serous acinar cells (Barnes: Pathology and Genetics of Head and Neck Tumours, 1st Edition. Acinic Cell Carcinoma Papillary Cystic Variant (ACC-PCV) is a distinct subtype and shows variegated appearance on cytology. It is important to differentiate it from other malignant lesions because of its poor prognosis. We describe a case of 20-year-old female with swelling on left cheek for the last four months Acinar cell carcinoma (ACC) of the pancreas is extremely uncommon and its cytologic features have rarely been described. We describe the cytologic features of cases we have seen, review the literature regarding its cytologic features and discuss the pitfalls that may be encountered and the use of immunohistochemistry for its diagnosis

Two Unusual Cases of Acinic Cell Carcinoma: Role of

Acinic Cell Carcinoma, Cytological Findings SpringerLin

Comments: Cell Types: Acinic cell carcinomas are composed of an admixture of different cell types, including a) acinar cells which are large polygonal cells with abundant basophilic granular cytoplasm (due to zymogen-like granules) and eccentrically placed small hyperchromatic nuclei; b) clear or vacuolated cells; c) intercalated duct-like cells which are cuboidal or columnar cells with. Among them, acinic cell carcinoma (ACC) is extremely rare and its cytological features have not been reported. We present a case of bronchial ACC and describe its cytological characteristics. The tumor occurred in a 58-yr-old man as a 15-mm polypoid lesion at the right middle lobar bronchus and filled its lumen Mucoepidermoid carcinoma, acinic cell carcinoma, and adenoid cystic carcinoma on fine-needle aspiration biopsy and The Milan System: an international multi-institutional study J Am Soc Cytopathol . Sep-Oct 2019;8(5):270-277. doi: 10.1016/j.jasc.2019.04.001 Papillary cystic variant of acinic cell carcinoma (ACC-PCV) occurs in younger patients as compared to the classic type, which presents in fifth decade of life. Acinic cell carcinoma (ACC) is a low grade malignancy with 5-year survival of 90% while ACC-PCV is universally fatal in 10 years Visit Cytoweb for more! https://blog.nus.edu.sg/cytoweb

Acinic Cell Carcinoma •Malignant epithelial neoplasm characterized by cytologic differentiation toward serous acinar cells (distinctive zymogen type secretory granules) •Second most common epithelial malignancy of the salivary gland (about half as frequent as mucoepidermoid carcinoma) •80% arise in the parotid glan Introduction. Acinic cell carcinoma (AcCC) is the second most common malignant neoplasm of the salivary glands, is located most commonly in the parotid gland, and derives from the acinar epithelium. 1 The diagnosis of AcCC by fine-needle aspiration (FNA) is often challenging. First, AcCC may appear similar to other benign and malignant neoplasms with oncocytic, vacuolated, or clear cell. The study cohort was composed of 10 cases of low-grade acinic cell carcinoma, 1 case of dedifferentiated high-grade ACC-SG, 3 cases of non-neoplastic salivary gland processes (chronic sialadenitis), 39 cases of benign salivary gland neoplasms, and 17 cases of malignant salivary gland neoplasms Acinar cells: large cells with serous or mucinous cytoplasmic content and small nuclei. Zymogen granules are often seen in the cytoplasm. It is very important to find ductal cells related to the acinic ones because if the former are missing we have to think of a well differentiated acinic cell carcinoma

FULL TEXT - Diagnosis of a case of papillary-cystic

Acinic-cell carcinoma, papillary-cystic variant: a

  1. Papillary cystic variant of acinic cell carcinoma is a rare, cystic, primary neoplasm of salivary gland that occurs commonly in parotid .The tumor shows high local recurrence rate and has poorer prognosis compared to classic acinic cell carcinoma. Preoperative cytological diagnosis of papillary cystic variant of acinic cell carcinoma of parotid.
  2. Considered diagnoses included acinic cell carcinoma, an oncocytic or sebaceous neoplasm, pleomorphic adenoma and epithelial myoepithelial carcinoma. Based on cytoplasmic granules a diagnosis of acinic cell carcinoma was rendered. 3.2
  3. Cytology and cytochemistry of acinic cell carcinoma. Franzén L, Carlsöö B, Angström T. In a primary material of 314 epithelial parotid tumours treated at the University Hospital in Umeå since 1958, fiften (11 female and 4 male patients) were classified as acinic cell carcinomas. Four of the female patients were in the age range 16--19 years
  4. antly found in parotid gland and rarely in submandibular gland or
  5. Three aspirates diagnosed as acinar cell carcinoma by cytology proved to be chronic pancreatitis (2 cases) and ductal adenocarcinoma (1 case). CONCLUSIONS. Acinar cell carcinoma has a distinctive cytological appearance but is frequently misdiagnosed on cytology. Immunocytochemistry is useful for identifying acinar differentiation

Acinic Cell Carcinoma:: Cytologic Features and Diagnostic

  1. or salivary gland, acinic cell carcinoma, FNA cytology. Introduction Acinic cell carcinoma is a relatively uncommon malignancy, accounting for 1-6% of all salivary gland tumors and 15% of all malignant tumors of the parotid gland. 1 Acinic cell carcinoma (ACC) is a rare, slow growing, low grade neoplasm of salivary glands and.
  2. Objective: Acinic cell carcinoma (ACC) of the salivary gland is difficult to diagnose cytologically because it shows variable morphology, resembles normal acinic cells, and seldom contains atypical cells. Study Design: We studied the architecture of ACC cell clusters and tumor cells, and compared its cytological features with histopathological findings
  3. Keywords: Acinic cell carcinoma, cytology, histopathology, papillary cystic variant, parotid How to cite this article: Dhar SS, Rautray S, Majumdar SK, Kar A, Parida DK. Papillary cystic variant of acinic cell carcinoma of parotid with preoperative diagnostic difficulty on fine-needle aspiration cytology: A case report

Acinic cell carcinoma Eurocytolog

KEY WORDS: acinic cell carcinoma; cytology; DOG1; nuclear receptor subfamily 4 group A member 3 (NR4A3); salivary gland. INTRODUCTION Acinic cell carcinoma (AcCC) is the second most common malignant neoplasm of the salivary glands, is located most commonly in the parotid gland, and derives from the acinar epithelium.1 The diagnosis of AcCC b FNA cytology of secretory carcinoma. Positive stains. CK7: 100% sensitive, nonspecific when compared with acinic cell carcinoma (Am J Surg Pathol 2010;34:599) GATA3: 100% sensitive; useful to distinguish from histologic mimic acinic cell carcinoma but nonspecific (53%). Carcinomas with oncocytic / oncocytoid cells or prominent lymphocytic infiltrates falsely interpreted as Warthin tumor or oncocytoma, ex: Warthin-like variant of mucoepidermoid carcinoma, mucoepidermoid carcinoma with lymphoid cuffing, acinic cell carcinoma with / without lymphoid infiltrates, secretory carcinoma → SUMP with oncocytic. Acinic cell carcinoma (ACC) is a low-grade malignant salivary neoplasm that constitutes approximately 17% of primary salivary gland malignancies. In the head and neck region, the parotid gland is the predominant site of origin and women are usually more frequently diagnosed than men Acinar cell carcinoma. It is a rare, aggressive malignancy, usually arising in adults, but it has been reported in children and adolescents as well. Cytologic diagnostic features. Groups of cells in nests, cords or acini; Single cells; Nuclear irregularity, crowding, overlapping; Increased N/C ratio; Conspicuous nucleoli; Moderately abundant.

Acinic Cell Carcinoma is a low-grade neoplasm occurs on the epithelial cell lining of the salivary gland. A gradual mass progression of the terminal end of the parotid gland usually affected. Almost 17 percent of the primary salivary gland carcinoma is related to the Acinic Cell Carcinoma The oncocytic or oncocytoid aspirate has a broad differential diagnosis, but main considerations include oncocytoma, oncocytic cystadenoma, Warthin tumor, mucoepidermoid carcinoma, acinic cell carcinoma, mammary analogue secretory carcinoma, and salivary duct carcinoma ().Oncocytoma, oncocytic cystadenoma, and Warthin tumor have a similar cytomorphologic appearance in that aspirates contain. Acinic cell carcinoma (ACC) of the salivary glands is a low grade malignancy which can present with late recurrences and distant metastasis. Being relatively resistant to chemotherapy, managing metastatic ACC is a clinical challenge, especially considering the long duration of survival of these patients Primary pulmonary acinic cell carcinoma (ACC) is rare. The clinicopathological features are not identical to that of classic ACC that leads to misdiagnosis. In this article, we summarized the clinicopathological features of 25 such cases, including 6 cases in this series and additional 19 cases in the literature

Social Media: The overall diagnostic accuracy was 76.6% for mucoepidermoid carcinoma, 71.8% for acinic cell carcinoma and 88.9% for adenoid cystic carcinoma according to the Milan System for Reporting Salivary Gland Cytology (MSRSGC) in an international multi-institutional study Usually, acinic cell carcinoma is prone to be underdiagnosed because of the cytological similarity of the tumor cells to normal acinar cells, however rarely, a predominant papillary architecture on cytology may cause confusion with adenocarcinomas. We present a case of a 45-year-old male with a painful swelling of the right parotid region. Acinic cell carcinoma. H&E stain. Acinic cell carcinoma, abbreviated AcCC, is a rare type of salivary gland cancer. It is also known as acinic cell adenocarcinoma . It should not to be confused with pancreatic acinar cell carcinoma

Usually, acinic cell carcinoma is prone to be underdiagnosed because of the cytological similarity of the tumor cells to normal acinar cells, however rarely, a predominant papillary architecture on cytology may cause confusion with adenocarcinomas. We present a case of a 45-year-old male with a painful swelling of the right parotid region Fine-needle aspiration cytology (FNA) can pose diagnostic difficulties due to the overlapping cytological features with acinic cell carcinoma (AciCC), mucoepidermoid carcinoma (MEC), oncocytic salivary neoplasms, low-grade cystadenocarcinoma, and pleomorphic adenoma (PA) Objectives: Acinic cell carcinoma (ACC) accounts for 12-17% of primary salivary gland carcinomas and 3.4% of all salivary gland neoplasms. ACC‐papillary cystic variant (PCV) is a distinct subtype with clear‐cut and well‐defined morphological features as revealed in tissue sections, but it is more difficult to diagnose accurately on fine needle aspiration (FNA)

Pathology Outlines - Acinar cell carcinom

3.1. Acinic cell carcinoma. Acinic cell carcinoma (AcCC) comprises one of six parotid cancers which is supported by a nationwide study in the Netherlands where 15% of parotid malignancies were AcCC [21-23]. Based on 1973-2009 Surveillance, Epidemiology, and End Results (SEER) analysis AcCC comprises 11% of salivary malignancies . AcCC has. Diagnosis of a case of papillary-cystic variant of acinic-cell carcinoma on fine needle aspiration cytology: Myriad of cytomorphological features. Int J Case Rep Imag 2014;5:18-22. [Doi: 10.5348/ijcri-2014-01-431-CR-4]. 5 Ali SZ. Acinic-cell carcinoma, papillary-cystic variant: A diagnostic dilemma in salivary gland aspiration Acinic cell carcinoma, clear cell variant. Hyalinizing clear cell carcinoma. Epithelial-myoepithelial carcinoma. Metastatic clear cell carcinoma. Metastatic clear cell renal cell carcinoma. Basaloid neoplasms. Basal cell adenoma. Basal cell adenocarcinoma; Pleomorphic adenoma. Adenoid cystic carcinoma. Small cell carcinoma. IHC overview. General

Video: Acinic Cell Carcinoma Papillary-Cystic Variant: Diagnostic

Acinic cell carcinoma is a rare breast tumour belonging to salivary gland-like tumours of the breast. They are triple-negative breast cancers even if their biological behaviour seems to be more favourable. Herein we present an acinic cell carcinoma arising on a background of typical and atypical microglandular adenosis in a 58-year-old woman, along with a review of the literature This is particularly valid when dealing with rare tumor types, such as the papillary-cystic variant of acinic-cell carcinoma (ACC-PCV), resulting in a high rate of false-negative cytologic diagnoses. Seven cases of ACC-PCV diagnosed on tissue resection with a prior FNA performed in cytology were studied

17 Best images about Learning Cytology on Pinterest

Salivary gland‐type carcinomas of the lung are rare but well‐known tumors. Among them, acinic cell carcinoma (ACC) is extremely rare and its cytological features have not been reported. We present a case of bronchial ACC and describe its cytological characteristics. The tumor occurred in a 58‐yr‐old man as a 15‐mm polypoid lesion at the right middle lobar bronchus and filled its. Acinar Cell Carcinoma (38 unread) Google - Acinar Cell Carcinoma (25 unread) PubMed - Acinar Cell Carcinoma (12 unread) Trial - Acinar Cell Carcinoma (1 unread) Acinic Cell Carcinoma (31 unread) Google - Acinic Cell Carcinoma (12 unread) PubMed - Acinic Cell Carcinoma (19 unread In general the cytology does not suggest highly malignant change! The morphology of the myoepithelial cells is evident on histology: the cells are arranged in groups, they show S100, PanCK positivity. The smear shows the presence of polymorphic myoepithelia cells mixed up with normal, large salivary gland acinic cells

Nagel H, Laskawi R, Büter JJ, Schröder M, Chilla R, Droese M. Cytologic diagnosis of acinic-cell carcinoma of salivary glands. Diagn Cytopathol 1997;16:402-12. 67 Metastatic papillary thyroid carcinoma. 7. 35 year old female, FNA Metastatic squamous cell ca. Metastatic melanoma. Amebic abscess. 8. 69 year old male. - A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 3ca8d-MzM2 Salivary Gland Cytology and The Milan System for Reporting Dina R. Mody, MD Director of Cytology laboratories The Ibrahim Ramzy Chair in Pathology Houston Methodist Hospital Professor of Pathology and Laboratory Medicine Weill Cornell Medicine Acinic cell carcinoma

serous acinar cell differentiation 80. Sections through a superficial parotidectomy for an acinic cell carcinoma reveal a sharply demarcated tumor with a partially cystic appearance. 81. Acinic cell carcinoma. The cells have an abundant cytoplasm filled with basophilic zymogen granules Acinic cell carcinoma The WHO manual defines acinic cell carcinoma is a malignant salivary gland epithelial neoplasm composed of neoplastic acinar cells. An acinus is shown in Figure 1A. ICD-O code 8550/3. Synonyms. Acinic cell adenocarcinoma; acinar cell. carcinoma. Localization. More than 90-95% of acinic cell carcinomas occur in the parotid glands (Figure 1 B) Examples of problematic cases. A, Case of pleomorphic adenoma incorrectly diagnosed as acinic cell carcinoma by several Nongynecologic Cytology Program participants (Papanicolaou stain, original magnification ×200). B, Case of acinic cell carcinoma incorrectly diagnosed as normal salivary gland (Papanicolaou stain, original magnification ×200) Differentiating adenoid cystic carcinoma (AdCC) from other basaloid neoplasm in a fine needle aspiration (FNA) sample can be challenging. Activation of MYB in AdCC by the fusion transcript MYB-NFIB has been recently demonstrated in salivary gland and other organs. The aim of this study is to evaluate the utility of MYB immunohistochemistry (IHC) in distinguishing AdCCs and other basaloid. Mucoepidermoid carcinoma, acinic cell carcinoma, and adenoid cystic carcinoma on fine-needle aspiration biopsy and The Milan System: an international multi-institutional study The Milan System for Reporting Salivary Gland Cytology; Publication forum classification. Publication forum level 1; Access to Document

Cytology of pancreatic acinar cell carcinom

Acinic cell carcinoma is a low-grade salivary gland carcinoma characterized by serous differentiation. Given the recent discovery of SC, a salivary gland carcinoma that mimics ACCi both on histology and on cytology, we undertook a reevaluation of ACCi diagnosed at our institution [ 1 , 4 - 8 ] [28] Acinic cell carcinoma was diagnosed in 4 (3.50%) cases, 2 cases each were seen in parotid and submandibular glands and was seen in 3rd and 5th decade which is similar to the study conducted by Fernandes GC et al.15 Two case of adenoid cystic carcinoma were diagnosed involving the minor salivary glands which are also similar to other. Acinic cell carcinoma with high-grade transformation. Slide Seminar of the Head and Neck Session of the 25th European Congress of Pathology (September 2013); Lisbon, Portugal. Link to PubMed Acinic cell carcinoma is commonly misdiagnosed as benign, due to its similarity with the salivary gland acini. There are limited studies about the value of DOG1 in the diagnosis of ACC. In our study, we examined DOG1 expression on destained alcohol fixed smears of ACC to assess the role in diagnosis The close differential diagnosis of SC in salivary gland is Acinic cell carcinoma (AciCC) which accounts for 12-17% of primary salivary gland neoplasm. Both tumors share common architectural patterns and cytomorphology. AciCC is characterized by zymogen granules in the cytoplasm; however, the zymogen granule poor AciCC i

Cytology of pancreatic acinar cell carcinoma — Experts

Application of fine needle aspiration cell blocks in the diagnosis of acinic cell carcinoma WANG Miao,YU Xiao-meng Department of Pathology,Beijing Friendship Hospital,Beijing 100050,China METHODS RESULTS Acinic cell carcinoma(ACC)is a rare low grade epithelial malignant tumor of salivary gland,which is liable to be missed or misdiagnosed A lymphoid‐rich stroma is a common finding in salivary gland tumors. Several reports documented this association with acinic cell carcinoma (ACC). However, cytologic studies reporting this phenomenon.. Acinic cell carcinoma is an uncommon salivary gland tumor, making up 1% of all salivary gland neoplasms. They most often arise in the parotid gland, but may occasionally involve the submandibular, minor salivary or seromucinous glands. ACCs are more frequently diagnosed in the fourth to sixth decades of life. It is the least aggressive of. The two acinic cell and 4 adenoid cystic carcinoma were also correctly recognized in our series. According to the experience of Shaha et al. [ 29 ] the diagnosis of the malignant lymphoma using the aspirated cytology is possible

Acinic Cell Carcinoma - Salivary Gland Cytology - Wiley

Abstract: Acinic cell carcinoma (ACC) is a rarely seen, slowly growing, low-grade malignant neoplasia of the salivary gland. ACC is most frequently detected in the parotid gland, rarely it is localized in a minor salivary gland. Rarely psammoma bodies are seen in neoplasic, and nonneoplasic lesions of the salivary gland Eneroth CM, Jakobsson P, Zajicek J. Aspiration biopsy of salivary gland tumors. V. Morphologic investigations on smears and histologic sections of acinic cell carcinoma. Acta Radiol Suppl. 1971;310:85-93. Epub 1971/01/01 PubMed Google Schola Case 56. Diagnosis: soft tissue cytology soft tissue FNA. Case 55. Diagnosis: neuroendocrine neoplasm Pancreatic neuroendocrine tumor PanNET. Case 54. Diagnosis: acinar cell carcinoma. Case 53. Diagnosis: colon adenocarcinoma metastatic colon adenocarcinoma. Case 52 Part of the highly regarded Diagnostic Pathology series, this updated volume by Drs. Dina R. Mody, Michael J. Thrall, and Savitri Krishnamurthy, is a visually stunning, easy-to-use reference covering all aspects of cytology, including gynecologic, non-gynecologic exfoliative, fine-needle aspiration, and imaging.An abundance of high-quality images make this an invaluable diagnostic aid for.

Acinic Cell Carcinoma With High-grade Transformation: A Report of 9 Cases With Immunohistochemical Study and Analysis of TP53 and HER-2/neu Genes. Skálová A, Sima R, Vanecek T, Muller S, Korabecna M, Nemcova J, Elmberger G, Leivo I, Passador-Santos F, Walter J, Rousarova M, Jedlickova K, Curik R, Geierova M, Michal M. Am J Surg Pathol. 2009. Acinic cell carcinoma is a rare cancer of the salivary glands that originates from the parotid gland. It is a low-grade salivary neoplasm that constitutes about 5% to 17% of cases involving.

Pathology Outlines - Acinar cell carcinoma

Cytomorphologically, acinic cell carcinoma is characterized by generally low cytonuclear grade cells with abundant foamy and coarsely granular cytoplasm. 16, 17 Similarly, it has recently been shown that mammary analogue secretory carcinoma has similar cytomorphology but with more multivacuolated cytoplasm, in contrast to the granular cytoplasm. Looks like grapes on cytology. 3) Fat (esp. in parotid) Also: lymph nodes (esp. in parotid, where salivary gland can be within benign lymph nodes). Acinic cell carcinoma NR4A3 translocations Epithelial-Myoepithelial Carcinoma PLAG1/HMGA2 translocations or HRAS mutation Mucoepidermoid carcinoma Hyalinizing clear cell carcinoma Epithelial-myoepithelial carcinoma Acinic cell carcinoma The microscopic approach 1. Invasion 2. Cellular composition 3. Architecture 4. Cytology 5. Stroma Stroma • eosinophilic hyaline material = myoepithelial cells • intraluminal material = ductal cells • stromal mucin common; no. • Acinic cell carcinoma Other malignant tumors 60 • Malignant mixed tumor • Malignant nerve sheath tumor • Embryonal rhabdomyosarcoma • Primary lymphoma Tumor-like lesions 62 • Sialadenitis • Salivary gland duct cyst Essentials of cytology: an atlas, Igaku-Shoin, New York, 199

Salivary gland pathoology 1

Journal of Cytology (2018-01-01) . Papillary pattern in acinic cell carcinoma of parotid gland: A potential diagnostic pitfall on FNA Acinic cell carcinoma is an uncommonly encountered malignant neoplasm of the major salivary glands and, most commonly, arises in the parotid gland. Needle aspiration cytology of the mass was suspicious for neoplasm. A completion parotidectomy was performed, and an acinic cell carcinoma was diagnosed . The patient underwent radiation therapy. High-grade transformation of acinic cell carcinoma (AciCC) (previously referred to as dedifferentiation) is a rare phenomenon characterized by histologic progression of low-grade AciCC to high-grade adenocarcinoma or undifferentiated carcinoma. We report 9 new cases with immunohistochemical analysis and examination of HER-2/neu and p53 genes to further define the profile of this tumor Keywords: Acinic cell carcinoma, Imprint cytology, Salivary gland. Full Text PDF [6893K] Abstracts References(7) Cited-By(1) Background:Acinic cell carcinoma is not a rare tumor in the salivary gland. Although the histopathology has been well-characterized recently, cytologic features has not been described well.. malignancy, followed by adenoid cystic and acinic cell carcinoma. Although most salivary malignancies are asymptomatic, presentation with a rapidly enlarging mass may be accompanied by pain, functional neurologic deficits, soft-tissue invasion, or nodal grade on cytology may vary between institutions.27 Also, most patients with salivary.

Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events abundant acinic cell carcinoma adenoid cystic carcinoma appearance associated atypia B-cell B-cell lymphoma background basal cell adenoma basaloid benign cellular characteristic chromatin clear cell clinical clusters common contain cytologic features cytoplasm demonstration develop differential diagnosis difficult diffuse disease distinction. The entity, acinic cell carcinoma, derives its name from the presence of numerous disorderly arranged microacinar structures that resemble the normal acini of benign salivary gland tissue . Typically, the smear pattern from aspirates of acinic cell carcinoma is loosely cohesive; tightly cohesive epithelial fragments are not seen Acinic cell carcinoma (ACC) is a rare histological type of malignant epithelial neoplasm exhibiting acinic cell differentiation. The typical locations are major and minor salivary glands and pancreas, where it accounts for approximately 10% and 1% of all cancers, respectively [1-3].ACC has been occasionally observed in other organs, including lung, stomach, liver, retroperitoneum, lacrimal. • Acinic cell carcinoma - Prominent asiner structures. 04.05.2017 14 Oncocytic carcinoma Salivary duct carcinoma • Overtly malignant cytology • Polygonal cells with abundantcytoplasm • Large hyperchromatic, pleomorphic nuclei • ProminentnucleoliProminent nucleol

Cytomorphologic and Immunophenotypical Features of Acinar

Acinic cell carcinoma (ACC) is a rare, slow-growing, low-grade salivary gland cancer. Most ACC occur in the parotid gland, representing between 2 and3% of all epithelial parotid neoplasms (1-3). The reported 10-year survival rate is approximately 70% (4-5). However, ACC has a tendency to develop local recurrence in 40 to 50% of the patients. An Acinic Cell Carcinoma (ACC) of Salivary Gland is a type of malignant epithelial tumor affecting either the major or minor salivary glands. It is observed in a wide age category of both children and adults. The cause of formation of this salivary gland malignancy is generally unknown, but may be due to genetic factors

Cytological diagnosis of cervical adenocarcinoma and

Acinic Cell Carcinoma : Cell Types - WebPatholog

To the Editor.—We refer to the 2003 publication by Lee et al1 of pulmonary acinic cell carcinoma (ACC) associated with perineural invasion and lymph node metastasis that was diagnosed in our department. This case is highlighted again because the tumor recurred 20 months following surgery, a phenomenon not previously described Acinic cell carcinoma FNA Cytology Play. Sympt40mes et diagnostic du carcinome à cellules Acinic. Les patients présentant le carcinome à cellules acinic se présenteraient habituellement avec. acinic cell carcinoma. An extremely rare carcinoma that is morphologically identical to the same-named tumours of the salivary glands. There is little known about their behaviour, but they do metastasise to regional lymph nodes and may be fatal. Microglandular adenosis, apocrine carcinoma Primary acinic cell carcinoma (ACC) of the lung is rare.1 Since the first case was described by Fechner in 1972,2 only 14 other cases have been reported in the literature, and of these, only 1 demonstrated metastasis to a regional lymph node3 and none was associated with perineural invasion. We report a case of primary ACC of the lung with. Acinar cell carcinoma is a rare aggressive tumor that occurs predominantly in adults with a mean age of 62 years, but also represents about 15% of pancreatic neoplasms in children. A few patients develop a syndrome characterized by subcutaneous fat necrosis and polyarthralgia caused by excessive lipase in the serum secreted by this type of tumors

Medullary thyroid carcinoma

Fine-needle aspiration cytology of bronchial acinic cell

Cytology Atypical Bland Atypical Gland profile Angulated Compressed Solid/cribriform Tall Cell Carcinoma with Reverse Polarity: Acinic Cell Carcinoma: Clear to granular epithelial cells containing zymogen granules arranged in glands and solid sheets. Triple negative Keywords: Acinic cell carcinoma, parotid gland, prognosis, parotidectomy Introduction Acinar cell carcinoma (ACC) is a relatively rare malignancy of the salivary gland and accouts for 6-8% of salivary gland tumors and 17% of parotid malignancies [1]. ACC is often found in parotid (80-90%) and occasionally identified i

Cytodiagnosis of cutaneous metastasis from renal cell

Mucoepidermoid carcinoma, acinic cell carcinoma, and

We evaluated the diagnostic accuracy (DA), risk of neoplasm (RON), and risk of malignancy (ROM) for the commonly encountered malignant salivary gland tumors mucoepidermoid carcinoma (MECa), acinic cell carcinoma (ACCa), and adenoid cystic carcinoma (ADCa) applying The Milan System for Reporting Salivary Gland Cytology (MSRSGC).The cytology archives from 2007 to 2017 of 9 academic institutions. Acinar cell carcinoma (ACC) of the pancreas is extremely uncommon and its cytologic features have rarely been described. We describe the cytologic features of cases we have seen, review the literature regarding its cytologic features and discuss the pitfalls that may be encountered and the use of immunohistochemistry for its diagnosis. We searched our databases for all cases of histologically. 43. Myoepithelial Carcinoma and Basal cell carcinoma are difficult to differentiate from their benign counterpart on FNA. Depends on histological findings of infiltration of surrounding tissue and perineural invasion Other rare primary malignant tumour of salivary gland include clear cell ca. NOS, carcinosarcoma, adenocarcinoma NOS, small cell.

Squamous cell carcinoma, Undifferentiated carcinomaClear Cell Renal Cell Carcinoma: Fuhrman Nuclear Grade

May 23, 2011 - Warthin tumor. two diagnostic features of Warthin tumor: oncocytic epithelium and lymphocytes. The epithelium is arranged in vaguely papillary fragments, composed of oncocytic cells with granular cytoplasm. The cells have prominent nucleoli, but have low nuclear/cytoplasmic ratios Synonyms for Acinic cell carcinoma in Free Thesaurus. Antonyms for Acinic cell carcinoma. 1 synonym for ACC: Air Combat Command. What are synonyms for Acinic cell carcinoma Salivary gland tumors begin when some cells in a salivary gland develop changes (mutations) in their DNA. A cell's DNA contains the instructions that tell a cell what to do. The changes tell the cells to grow and divide rapidly. The abnormal cells go on living when healthy cells would die. The accumulating cells form a tumor Although a rare intranuclear pseudoinclusion was present, no overt cytologic atypia or areas of necrosis were observed.The differential diagnosis is extensive and includes primary tumors in the lung such as clear cell variant of bronchogenic carcinoma and acinic cell carcinoma as well as metastatic clear cell tumors acinic: ( as'i-năr ), Pertaining to the acinus. Synonym(s): acinic Median overall survival for acinar cell carcinoma of the pancreas has been reported to be 18.7 months with a 68% 1-year survival . Cases of resectable acinar cell carcinoma have an average disease-free survival of 9 months . We report an above average survival of 37 months after the initial diagnosis of acinar cell carcinoma of the pancreas

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