Background and purpose: Understanding the mechanisms underlying progression/regression of symptomatic intracranial atherosclerotic stenosis (sICAS) will inform secondary prevention of the patients. Focal wall shear stress (WSS) may play an important role, which, however, had seldom been investigated Background and purpose: Intracranial atherosclerosis is one of the main causes of stroke, and high-resolution magnetic resonance imaging provides useful imaging biomarkers related to the risk of ischemic events In symptomatic atherosclerosis, plaque enhancement regresses over time after ischemic stroke, which may offer the potential to monitor the plaque activity in intracranial atherosclerosis using HRMRI
Plaque regression and stabilization An ischemic event is usually associated with an advanced atherosclerotic lesion. Early studies in animals showed that removal of atherogenic factors reduced the prevalence of atherosclerotic lesions The main outcome was stenosis (≥50%) in the artery with the largest obstruction among the 12 cerebral arteries. We used multivariable logistic regression models to investigate the association between EAD and IAD. RESULTS: In 661 participants (mean age = 71.3 ± 11.7 y, 51% male), stenosis was more common in IAD than in EAD (59% vs. 51%) The multiple logistic regression analyses showed that when apo A1 > 1.28 g/L, it was an independent protective factor of intracranial stenosis (OR, 0.39), apo B was an independent risk factor of the cerebral atherosclerosis stenosis group, and when apo B > 1.16, it is significantly associated with the cerebral atherosclerosis stenosis group.
Background and Purpose: Intracranial atherosclerosis is one of the main causes of stroke, and high-resolution magnetic resonance imaging provides useful imaging biomarkers related to the risk of ischemic events Background: The outcome of patients with symptomatic intracranial atherosclerosis who fail antithrombotic therapy is unknown. These patients may represent the target group for investigation of more aggressive therapies such as intracranial angioplasty Objective: To explore the association of intracranial atherosclerotic disease (ICAD) with mild cognitive impairment (MCI) and dementia. Methods: From 2011 to 2013, 1,744 participants completed high-resolution vessel wall MRI from the population-based Atherosclerosis Risk in Communities Study by a sampling strategy that allowed weighting back to the cohort. We defined ICAD by plaque features. Intracranial atherosclerosis can result in thromboembolism with or without hypoperfusion leading to transient or permanent cerebral ischaemic events. High rates of recurrent ischaemic stroke and other cardiovascular events mandate early diagnosis and treatment Patients with intracranial atherosclerotic disease (ICAD) have a high frequency of stroke recurrence. However, there has been little investigation into the prognostic value of higher‐resolution magnetic resonance imaging (HR‐MRI)
Intracranial atherosclerosis is a prevalent cause of ischemic stroke worldwide, especially in the Asian population .Both luminal stenosis and vulnerable plaques contribute to ischemic events Symptomatic intracranial atherosclerosis (ICAS) is a dynamic disease that frequently progresses. Statins have been shown to have anti-atherosclerotic activity. We therefore investigated whether statins could prevent progression of ICAS Medical Treatment of Patients with Intracranial Atherosclerotic Disease. Journal of Neuroimaging, 2009. Adnan Qureshi. Download PDF. Download Full PDF Package. This paper. A short summary of this paper. 37 Full PDFs related to this paper. READ PAPER . This study aimed to investigate the association of type 2 diabetes mellitus and glycemic control with the characteristics of intracranial plaques using vessel wall MR imaging. MATERIALS AND METHODS: In total, 311.
. During a mean follow-up period of 64.5 months, 32 (1.1%) volunteers had a cerebrovascular event: ischemic stroke in 26 (0.89%) volunteers and TIA in 6 (0.21%) volunteers Cite this article as: Xu WH, Li ML, Gao S. Intracranial plaque regression after intensive medical treatments: a highresolution MRI observation. Ann Transl Med 2014 Jul 28. doi: 10.3978/j.issn.2305-5839.2014.08.09 amlodipine 5 mg/day were prescribed. Eighty days after the treatments, ICA plaque regression was observed on repeated HR-MRI (Figure 1D) Logistic regression analysis of intracranial (a) and extracranial (b) atherosclerotic stenosis, among lipid ratios in the extreme quartiles of each evaluated variable. Data were adjusted for age, gender, current smoking, hypertension, diabetes mellitus, previous stroke, and coronary heart disease A potential treatment strategy for intracranial atherosclerotic disease may be aimed at medical therapies that induce plaque regression. The treatment with statins to stabilize and/or promote plaque regression of intracranial atherosclerotic lesions is largely inferred from data in the coronary literature
Introduction. Intracranial atherosclerotic disease (ICAD) is a major cause of ischemic stroke worldwide (1,2) and an important public health concern in the United States and globally.The prevalence of ICAD and associated luminal narrowing in the general population, however, is unknown because of the lack of appropriate diagnostic tools with which to depict intracranial vessel walls in. Introduction Recent studies have shown that insulin resistance (IR) is correlated to atherosclerosis development. However, few studies have investigated the association between IR and asymptomatic intracranial arterial stenosis (aICAS). Research design and methods This cross-sectional study enrolled 2007 rural residents in China who were aged ≥40 years without a clinical history of stroke.
Researchers explore the association between reduced kidney function and kidney damage with intracranial atherosclerotic disease. Skip to navigation in multinomial logistic regression models. Background The effect of cerebral small vessel disease (CSVD) and intracranial arterial stenosis (ICAS) on stroke outcomes remains unclear. Methods Data of 1045 patients with minor stroke or transient ischaemic attack (TIA) were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events (CHANCE) trial . Conditional logistic-regression was used to determine the association between risk factors and stroke subtypes
Atherosclerotic disease often involves the intracranial arteries including those encased by cranial bones and dura, and those located in the subarachnoid space. Age, hypertension, and diabetes mellitus are independent risk factors for intracranial atherosclerosis. Intracranial atherosclerosis can result in thromboembolism with or without hypoperfusion leading to transient or permanent cerebral. . All risk factors from table 2 that proved a group difference of p<0.1 were entered in a backward stepwise multinomial logistic regression
Intracranial Atherosclerotic Stenosis (ICAS) is associated with 8 to 10% of all strokes in the U.S. Although there is some evidence that in the Asian population inflammation plays a role in asymptomatic ICAS, it has not been shown in the U.S. population. Prior studies have shown associations between diet and regulation of inflammation Introduction. Intracranial atherosclerotic disease (ICAD) is a major ischaemic stroke subtype of high recurrence.1 In the Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) trial, risk of recurrent stroke or death for patients with high-grade ICAD was 12.6% in the first year despite optimal medical treatment.2 In the Chinese. The medical treatment of patients with symptomatic intracranial atherosclerotic disease (ICAD) is directed toward reducing the risk of new ischemic events. The overall strategy is divided into: (1) prevention of occurrence of intraluminal thrombus, with or without embolism; (2) plaque stabilization and regression; and (3) management of.
ing severe intracranial atherosclerotic stenosis (ICAS) is unclear. The purpose of this study was to compare treatment Multivariate logistic regression analysis revealed the only independent predictor of good outcome was a history of previous stroke or transient ischemic attack (TIA) (odds ratio 0.254, 95% confidenc The Chinese Intracranial Atherosclerosis (CICAS) study was designed to investigate the prevalence and analyse the risk factors for recurrent stroke in patients with large artery occlusive disease in China.17 The CICAS study found a higher prevalence of intracranial artery atherosclerosis compared with extracranial artery atherosclerosis (46% vs. Conclusions: Changes in atherosclerosis are more dynamic in patients with symptomatic ICAS, and the predictors of symptomatic and asymptomatic ICAS differ. In this study, changes in the status of symptomatic ICAS were associated with the level of HDL cholesterol, which is known to affect the regression of atherosclerosis and vascular remodeling
IMPORTANCE Intracranial atherosclerotic disease (ICAD) is an important cause of stroke; however, little is known about racial differences in ICAD prevalence and its risk factors. OBJECTIVE To determine racial differences in ICAD prevalence and the risk factors (both midlife and concurrent) associated with its development in a large, US. METHODS The authors performed a chart review and telephone interview of patients with symptomatic intracranial atherosclerosis identified in the Stanford Stroke Center clinical database. A Cox regression model was created to identify factors predictive of failure of antithrombotic therapy
BACKGROUND: Patients with intracranial atherosclerotic disease (ICAD) have a high frequency of stroke recurrence. However, there has been little investigation into the prognostic value of higher-resolution magnetic resonance imaging (HR-MRI). PURPOSE: To investigate the use of intracranial atherosclerotic plaques features in predicting risk of recurrent cerebrovascular ischemic events using HR. Patients with acute ischemic stroke or transient ischemic attack (TIA) attributed to 50% to 99% intracranial atherosclerotic stenosis were recruited. All patients underwent cerebral computed tomography angiography at baseline, and a computational fluid dynamics model was built based on computed tomography angiography to simulate blood flow and. Atherosclerosis is the most common cause of ischemic stroke worldwide and an important prognostic factor for recurrent vascular events. 1 Evidence is accumulating that development, distribution, and severity of atherosclerosis may be dependent on sex. 2,3 Several studies have shown that extracranial atherosclerosis is more common in men than in women with ischemic stroke. 4 Less is known about. Elevated serum uric acid (SUA) has been reported to be associated with an increased risk of cardiovascular diseases, but the role of SUA in intracranial atherosclerosis remains unclear. To investigate the association between SUA and intracranial atherosclerotic stenosis (ICAS), we evaluated 1522 subjects (305 with ICAS, 1217 without ICAS) with magnetic resonance angiography (MRA)
Racial differences in prevalence and risk for intracranial atherosclerosis in a us community-based population Ye Qiao , Fareed K. Suri, Yiyi Zhang, Li Liu, Rebecca Gottesman , Alvaro Alonso, Eliseo Guallar , Bruce A. Wasserma Predictors of symptomatic and asymptomatic intracranial atherosclerosis: What is different and why? Bum Joon Kim, Keun Sik Hong, Yong Jin Cho, Ju Hun Lee, Ja Seong Koo, Jong Moo Park, Dong Wha Kang, Jong S. Kim, Seung Hoon Lee , Sun U. Kwo Intracranial atherosclerosis (ICAS) is one of the most common causes of ischemic stroke in Asia.1 2 Mechanical thrombectomy with stent retrievers has been shown to be effective in acute ischemic stroke of the anterior circulation caused by intracranial large artery occlusion (ILAO) in several randomized controlled trials Intracranial atherosclerotic disease (ICAD) is estimated to account for 8% to 10% of all ischemic strokes 1 and carries a risk of recurrent stroke of approximately 15% per year without treatment. 2 Stroke from ICAD can be attributed to several mechanisms, including hypoperfusion, thromboembolism, and small-vessel occlusive disease. 3-5. Regression of intracranial artery stenosis. The two studies also reported the regression of symptomatic intracranial artery stenosis. There was no heterogeneity in the MRA or TCD results across studies (P = 0.49, I 2 = 0%), and a fixed-effects model was again adopted
Aims: The association of hyperglycemia and duration of diabetes with intracranial atherosclerotic stenosis (ICAS) in the general population is not well documented. We examined whether elevated glucose and longer diabetes duration is independently associated with ICAS in a community-based sample Atherosclerosis, 213:8-20.  Chung JW, Hwang J, Lee MJ, Cha J, Bang OY (2016). Previous Statin Use and High-Resolution Magnetic Resonance Imaging Characteristics of Intracranial Atherosclerotic Plaque: The Intensive Statin Treatment in Acute Ischemic Stroke Patients With Intracranial Atherosclerosis Study. Stroke, 47:1789-1796 Patients were classified into either an intracranial atherosclerotic disease (ICAD) group or an embolic group according to the corresponding angiographic findings. The baseline characteristics and functional outcomes were compared between the two groups. Multivariable logistic regression analysis was performed Computational Fluid Dynamics Modeling of Symptomatic Intracranial Atherosclerosis May Predict Risk of Stroke Recurrence. The association between neutrophil count and ICAS was evaluated by multivariable logistic regression analysis. Among 2847 individuals included in this study, individuals with ICAS had higher neutrophil counts than those. Intracranial atherosclerosis (ICAS) is an important cause of ischemic stroke worldwide, particularly in Asian, African American, and hispanic populations.1,2 The incidence of ischemic events in patients with symptomatic ICAS is almost four-fold greater than in patients with asymptomati
Endovascular treatment for emergent large vessel occlusion due to severe intracranial atherosclerotic stenosis 3-month modified Rankin scale score 0-2, and mortality between the two centers. Multivariate logistic regression analysis revealed the only independent predictor of good outcome was a history of previous stroke or transient. Background: Intracranial atherosclerotic stenosis (ICAS) is the most common cause of stroke, but the relationship of ICAS with fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA 1c) is unclear.This study aimed to investigate the effects of increased FBG and HbA 1c concentration on ICAS.. Results: Levels of fasting glucose and HbA 1c in patients with ICAS were significantly higher. Conditional logistic regression models were used to assess the relationship between angiographic variables of CAS and aneurysmal irregularity. Carotid Endarterectomy Trial found that 3.1% of patients with carotid stenosis had cerebral aneurysms, 7 possibly because atherosclerotic diseases and intracranial aneurysms share common risk factors. with intracranial atherosclerotic disease present with is-chemic strokes in the territory of the aﬀected artery. The mechanisms proposed in ischemia include artery-to-artery also reported a 14% regression in intracranial ICA stenosis and a 28% regression in the MCA-ACA-PCA group. The The natural history of stenosis secondary to intracranial atherosclerosis has been angiographically studied by Akins et al. . Over a follow-up period of more than 2 years, they found an increase in the degree of stenosis in the MCA-ACA-PCA group, whereas intracranial ICA stenoses remained stable with a 14% regression in intrac-ranial ICA.
In multivariate logistic regression analysis, after adjustment for gender, age, and group, the factors significantly associated with risk of large artery stroke were atherosclerosis in intracranial artery (OR, 1.763; 95% CI, 1.037-2.995; P=0.036), collateral type (OR, 0.350; 95% CI, 0.127-0.967; P=0.043), and collateral scale (OR, 2.254; 95. Unless breakthrough drugs that suppress the progression of intracranial atherosclerosis and the formation of thrombi, and facilitate the regression of the arterial stenosis, the treatment concept of the recovery of the blood flow of stenotic arterial territory by mechanical recanalization or bypass surgery would be remained for the prevention. Advanced intracranial atherosclerosis was defined in the same manner as the sum of the intracranial atherosclerosis burden, including the ACA, MCA, PCA, distal ICA, intracra- regression analysis that included variables with <0.05 in the p bivariate analysis. All of the statistical analyses were performe Multivariable logistic regression analysis including age, sex, vascular risk factors, body mass index, estimated glomerular filtration rate, high-sensitivity C-reactive protein, and calcification status showed that intracranial calcification was independently associated with an advanced cerebral atherosclerosis burden in a dose-dependent manner.
Association of Intracranial Atherosclerotic Disease with Brain β-Amyloid Deposition: Secondary Analysis of the ARIC Study Rebecca F. Gottesman, Thomas H. Mosley, David S. Knopman , Qing Hao, Dean Wong, Lynne E. Wagenknecht, Timothy M. Hughes, Ye Qiao, Jennifer Dearborn, Bruce A. Wasserma Accelerated atherosclerosis and increased stroke morbidity and mortality have been associated with RA [2,3,4,5]. According to a recent meta-analysis, there is an excess risk of stroke (ORs ranging from 1.51 to 2.13) . Yet, to date, no systematic evaluation of intracranial circulation has been performed
By using exploratory logistic regression analysis adjusted for patient background characteristics, it was shown that the risk for certain combinations of secondary endpoints was lower in the CA group than in the A group [all vascular events and silent brain infarcts: odds ratio (OR) = 0.37, p = 0.04; stroke and silent brain infarcts: OR = 0.34. Of those variables that influenced atherosclerotic lesion of the intracranial aneurysmal wall, the variable male (P = .005) and maximum RRT (P = .004) remained significant in the multivariate regression model (R 2 = 0.52). Cigarette smoking was not chosen by the forward stepwise method Intracranial atherosclerosis on 7T MRI and cognitive functioning - the SMART-MR study. July 17, 2020 | Brian Dougherty and Alex Chan. Facebook. Twitter. (b = -0.02 per +1 lesion, 95% CI -0.05 to 0.00, where b is a linear regression coefficient representing the difference in Z-score per one lesion increase in ICAS burden), even after. January 25, 2021 (Abstract from PubMed) Background and purpose: We aimed to determine the relationships of 33 biomarkers of inflammation, oxidation, and adipokines with the risk of progression of symptomatic intracranial atherosclerotic stenosis (ICAS)
Association of Subclinical Coronary Artery Disease and Ischemic Stroke Caused by Cervical or Intracranial Atherosclerosis. Cardiology and Cardiovascular Medicine 5 (2021): 17-31. were compared with bivariate logistic regression. Odds Ratios (OR) and 95% confldence intervals (95%CI) were calculated.. Intracranial atherosclerosis is the dominant cause of stroke in over 70% of the world's population. Globalization is leading to an increasingly heterogeneous society everywhere. Advances in imaging techinology allow this previously inaccessible pathology to be clinically studied. Edited by internationally renowned clinicians, Intracranial Atherosclerosis is the first book to examine. Background Patients with symptomatic intracranial atherosclerosis (ICAS) of ≥70% luminal stenosis are at high risk of stroke recurrence. We aimed to evaluate the relationships between hemodynamics of ICAS revealed by computational fluid dynamics (CFD) models and risk of stroke recurrence in this patient subset. Methods Patients with a symptomatic ICAS lesion of 70-99% luminal stenosis were. Background Intracranial atherosclerotic stenosis (ICAS) is an important cause of ischemic stroke worldwide. The role of high-density lipoprotein cholesterol (HDL-C) or low-density lipoprotein cholesterol (LDL-C) in the development of ICAS remains to be elucidated. In the current study, we investigated the relationship of HDL-C level and the risk of developing ICAS in Chinese patients with.
Regional High Wall Shear Stress Associated With Stenosis Regression in Symptomatic Intracranial Atherosclerotic Disease Linfang Lan, Haipeng Liu , Vincent Ip, Yannie Soo, Jill Abrigo, Florence Fan, Sze Ho Ma, Karen Ma, Bonaventure Ip, Jia Liu, Yuhua Fan, Jinsheng Zeng, Vincent Mok, Lawrence Wong, David Liebeskind, Thomas Leung, Xinyi Len BACKGROUND AND PURPOSE: Intracranial atherosclerosis, a major risk factor for ischemic stroke, is thought to have different atherogenic mechanisms than extracranial atherosclerosis. Studies investigating their relationship in vivo are sparse and report inconsistent results Objective Intracranial atherosclerosis is a major cause of ischaemic stroke worldwide. a number of studies have shown the effects of statin treatment on coronary and carotid artery plaques, but there is little evidence on the effects of statin treatment on intracranial atherosclerotic plaques. Methods The Intensive statin Treatment i In a multiple regression analysis, metabolic syndrome, but not conventional risk factors, was independently associated with intracranial atherosclerosis (P=0.016). By contrast, the serum level of C-reactive protein was correlated negatively with the presence of intracranial atherosclerosis
Intracranial atherosclerotic disease (ICAD) is one of the most common causes of stroke worldwide and the one with the worst prognosis. In this study, we assessed the hypothesis that the balance of circulating pro- and antiangiogenic factors plays a role in the evolution of the disease and can be used as a potential marker for the disease course. Atherosclerosis is a pattern of the disease arteriosclerosis in which the wall of the artery develops abnormalities, called lesions.These lesions may lead to narrowing due to the buildup of atheromatous plaque. Initially, there are generally no symptoms. When severe, it can result in coronary artery disease, stroke, peripheral artery disease, or kidney problems, depending on which arteries are. Evaluating intracranial atherosclerosis rather than intracranial stenosis. Stroke. 2014;45: 645-651. Leng XY, Chen XY, Chook P, et al. Correlation of large artery intracranial occlusive disease with carotid intima-media thickness and presence of carotid plaque. Stroke. 2013;44:68-72 Results: Coronary artery stenosis was observed in 25.4% of the patients and this was associated with age (OR: 1.16, 95% CI: 1.03-1.30) and the presence of stenosis of the extracranial carotid artery (OR: 11.37, 95% CI: 1.88-68.75) after logistic regression analysis. Intracranial arterial stenosis was not independently related to coronary stenosis Multiple logistic regression analysis showed that the lowest tertile of MMP-2 was independently associated with ICAS (OR 4.84, 95% CI 1.29-18.19, p = 0.022). Conclusion: Low MMP-2 plasma levels are associated with intracranial location of cerebral atherosclerosis, suggesting that MMP-2 may play a role in the development of ICAS
erosclerosis and intracranial atherosclerosis, is recognized as a major risk factor of stroke . Actually, atherosclerosis is an important role in the regression of atherosclerotic plaque [6, 9]. Researches show that the M2 phenotype could secret Background and Objective: Recently, AMP-activated protein kinase (AMPK) signaling was confirmed to be intimately associated with atherosclerosis. Evidence indicates that genetic susceptibility plays an important role in the etiology of symptomatic intracranial atherosclerotic stenosis (sICAS), however few genes have been pinpointed being etiologically associated hemorrhage (hĕm`ərĭj), escape of blood from the circulation (arteries, veins, capillaries) to the internal or external tissues.The term is usually applied to a loss of blood that is copious enough to threaten health or life. Slow bleeding may lead to anemia anemia, condition in which the concentration of hemoglobin in the circulating blood is below normal
An atheroma, or atheromatous plaque (plaque), is an abnormal accumulation of material in the inner layer of the wall of an artery.. The material consists of mostly macrophage cells, or debris, containing lipids, calcium and a variable amount of fibrous connective tissue.The accumulated material forms a swelling in the artery wall, which may intrude into the lumen of the artery, narrowing it.