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Deep philtrum baby

Deep philtrum. MedGen UID: long and prominent philtrum, and thick lips with a small mouth. Other characteristic features include hoarse voice and pseudomuscular build, and there are distinct skeletal features as well, including an internal notch of the femoral head, internal notch of the second metacarpal, and external notch of the fifth. A philtrum with the same width from the top to the base, like a train track, indicates the same amount of sons and daughters. A female with a deep, narrow top and wide base philtrum indicates a well-developed vagina and uterus. As a result, It will be relatively easy for her at baby delivery The deep, long and wide philtrum symbolizes many children. Deep and Long Philtrum. It means the well-defined, clear and sunken philtrum that belongs to the honest, kind, modest, polite and popular people, who are patient, persistent, and hardworking, make a prosperous career in middle age, and enjoy auspicious and blessed twilight years.. The Digital Image Format of Lip-Philtrum Guides 1 and 2. The digital image format of Lip-Philtrum Guides 1 and 2 are displayed below. They come with a frontal and 3/4 view of the lips and philtrums. The 3/4 view images help to further portray the distinctions beween the 5 philtrum ranks. The frontal photos are used to rank lip thinness 09/11/2013 16:16. Subject: Smooth philtrum but not FAS? Anonymous. I had to google it just to know what a philtrum was. Deep breath. Ask at your next peds appt and see what they say. It CAN be a symptom but not always. Don't stress. A month into pregnancy is technically only two weeks post conception

She goes to all her well baby checkups and my husband kept telling me if something was wrong they would have said something! I guess because of the eyes and the nose, and she dropped a little in height I freaked out! When she was 3 she went from 3125% in height to 18. You know I measured her philtrum and it was like 1.58 cm, so it was in. A smooth upper lip philtrum is a trait just like any other that can be influenced by genetic factors as well as factors present in the development of a fetus (like alcohol). It can be seen in fetal alcohol syndrome BUT can also be seen in many normal kids philtrum and the mouth and from the mouth to the upper concavity of the chin (Goldstein et al., 2010). www.intechopen.com. Normal and Abnormal Fetal Face 87 Fig. 2. Sonographic picture of the fetal face. Typical facial concavities and protrusions are presented. The calipers measured between the upper philtrum to the mouth (upper picture)

Deep philtrum (Concept Id: C1839797

Children with autism have a broader or wider mouth and philtrum - the groove below the nose, above the top lip. Autism Society This photo of a young boy with autism was not used in the study Deep philtrum baby Deep philtrum baby Comments. AmethystTrask on August 05, 2019:. For all those men commenters out there upset about their lack of a philtrum -- don't be downhearted. Christopher Pennock of Dark Shadows (the 60s gothic soap opera) had basically no philtrum and he had a huge following (I appreciate that's a weirdly old reference, but he was the first actor I could think of with a very under-defined philtrum who. An occasional finding on physical exam is an asymmetric appearance of the nose due to a positional deformity. Most likely, this results from an unfortunate position in utero. The nares in this case are asymmetric and slightly flattened towards the infant's right, even though the septum is still centrally located. photo by Janelle Aby, MD

Women's Faces show their Own Children's Fortune

  1. How the Baby Got Its Philtrum. S ometime after World War II, Humphrey Bogart, or rather Frank McCloud, goes out to the Florida Keys to visit the father (Lionel Barrymore) and young widow (Lauren Bacall) of a soldier who had been under his command in the Battle of San Pietro. The soldier's father asks McCloud to tell him something about how.
  2. For women, a long and deep philtrum means higher probability of having a baby boy; a flat and thick philtrum implies higher chance of having a baby girl. The pointed junction of this groove and the upper lip indicates baby boy while the round one indicated baby girl. If the philtrum is a little more to the left, the chance of first baby as a.
  3. Pucker up, baby! Lips take center stage in infants' brains, study says. A new University of Washington study shows how the hands, feet and, in particular, the lips are represented in the brains of 2-month-old infants. A typically developing 2-month-old baby can make cooing sounds, suck on her hand to calm down and smile at people
  4. A mother with deep and long philtrum will have a baby boy while the flat philtrum suggests higher probability of baby girl. A woman with small and slightly left philtrum is more likely to have a baby girl as the first child. Rules. The baby gender is matter of both husband and wife rather than one party. As a result, the face reading of both.
  5. The philtrum (Latin: philtrum from Ancient Greek φίλτρον phíltron, lit. love charm), or medial cleft, is a vertical indentation in the middle area of the upper lip, common to many mammals, extending in humans from the nasal septum to the tubercle of the upper lip.Together with a glandular rhinarium and slit-like nostrils, it is believed to constitute the primitive condition for at.
  6. Harriette Halepis Some folktales include the hypothesis that an angel's touch upon a baby creates a small indentation, or philtrum. The philtrum refers to the groove that most humans have above the upper lip.The philtrum is also referred to as the infranasal depression.This portion of the human face is formed during embryonic development

lip contour and volume augmentation with Perfectha Derm 1ml, long lasting HA up to 12 moths; visit www.dermafiller.ch for further informatio Deep philtrum MedGen UID: 374311 • Concept ID: C1839797 • Finding Accentuated, prominent philtral ridges giving rise to an exaggerated groove in the midline between the nasal [ncbi.nlm.nih.gov] Show info. Lymphedema - Cerebral Arteriovenous Anomaly Syndrome A female with a deep, narrow top and wide base philtrum indicates a well-developed vagina and uterus. As a result, It will be relatively easy for her at baby delivery. She will also have little gynecological diseases in the whole life. On the other hand, a female with an oblique philtrum may have a much higher chance of getting gynecological. In Jewish lore, a baby in the womb knows everything about the heavens until an angel comes and places a finger over its lips to keep it from spilling the heavenly beans. The angel's touch forms the philtrum. In Chinese face reading, the shape of the philtrum is used to make predictions about health or as a part of fortune telling

Face Reading Philtrum, Lip Crease, Vertical Groove on the

A baby with a lip tie may have an easier time drinking from a bottle. Milk that has been pumped from your breast, or formula you buy at the store, are both acceptable forms of nutrition FAS is a permanent birth defect syndrome caused by maternal alcohol consumption during pregnancy. The full FAS diagnosis requires all of the following: growth problems before or after birth, a pattern of minor facial anomalies, evidence of altered brain structure or function, and prenatal alcohol exposure. There is an associated increased risk. These may include an unusually deep vertical groove in the middle of the upper lip (philtrum); and/or a small chin. Affected infants may also have a small jaw (micrognathia); crowding of the lower teeth, low-set, posteriorly rotated external ears (pinnae); and/or distinctive abnormalities of the nose including a depressed nasal root, a wide. At ancient time, a person with deep Philtrum indicated that he/she could have more than 4 children. Today, due to the popularity of contraception, a person with deep philtrum should have more than 2 children. A person with shallow flat Philtrum, on the other hand, indicates no offspring or just one child

My baby is 12 months n 3 weeks old his upper lip tie is torn please help me to treat him . This is the first time I.ve seen in my life I don,t know how to handle it. Dickson Sep 21, 2019 / 3:50 pm My baby is 8weeks, and when trying to clean her tongue, I accidentally torn the lower frenulum, will it heal on it own or I need to take her to the. Have a wider mouth and philtrum - the area between the nose and lips She said: 'There is no clear answer about whether autism is caused by genetics or by environmental influences Normal Sonographic Anatomy of the Fetal Face. With two-dimensional (2D) ultrasound, a combination of planes must be used to assess facial anomalies (Fig. 11-1). 1, 3, 4, 6 The following discussion applies mostly to the midtrimester fetus. However, many details of facial anatomy can be identified as early as 11 weeks, particularly by using transvaginal sonography According to the study, children with autism also had a shorter middle region of the face - including the nose and cheeks - as well as a wider mouth and philtrum, the divot above the lip and below. 12. Deep nasal groove: If you notice deep grooves on the outside of the nostrils, this is showing low lung energy, chronic allergies, or a history of respiratory illness. This could be a general weakness in the area, although it most likely stems from a history of asthma, bronchitis, pneumonia, or something similar

According to face-mapping experts, the face directly connects to the rest of the body. Through the lines and marks on our skin and eyes, our bodies can send us messages and warning signs about our. Discolored skin above the mouth is a readout for digestive disorders according to Traditional Chinese Five Element Medicine. When something is going on in your gut, the skin color surrounding your mouth announces it. Off-colors include white, yellow, red, blue, green, brown or grey.

Lip-Philtrum Guides - University of Washingto

Take 1 tablespoon of avocado pulp, 1 tablespoon of lemon juice and 1 egg white. Mix them well to make a smooth paste and equally apply all over your face. Leave it on for 20 minutes and then wash off. 8. Tomato Juice. Application of tomato juice is an other great way to get rid of wrinkles around mouth In some instances low muscle tone in an infant may be one of the features of a rare disease or genetic syndrome. In this case fast, targeted genetic analysis can give you a more accurate diagnosis. Synonyms: Muscular hypotonia (abnormally low muscle tone) affecting the musculature of the trunk and with onset in infancy A baby's skin coloring can vary greatly, depending on the baby's age, race or ethnic group, temperature, and whether or not the baby is crying. Skin color in babies often changes with both the environment and health. Some of these differences are just temporary. Others, such as certain birthmarks.

Smooth philtrum but not FAS? - DC Urban Mo

Skin laceration repair is an important skill in family medicine. Sutures, tissue adhesives, staples, and skin-closure tapes are options in the outpatient setting. Physicians should be familiar. Second, a deep wound can be located in a cosmetically important part of a child's body such as the ears, nose, lips or eyelids. Fortunately, wounds of this severity represent only a small fraction of lacerations in children. Mark A. Brandenburg, MD. Emergency Physician at St. Francis Hospital in Tulsa, Oklahoma

Wrinkly skin syndrome is a genetic condition characterized by sagging or wrinkly skin, reduced skin elasticity, and delayed closure of the fontanel (a baby's soft spot on the top of his/her head). Other associated signs and symptoms vary widely. Case reports suggest that this condition is often inherited in an autosomal recessive fashion. It can be caused by mutations in the ATP6VOA2 gene The three main sections of the puzzle meet at your top lip, creating the groove that is the philtrum. The development of the face happens between months two and three of being in the womb. Ackerman syndrome is a familial syndrome of fused molar roots with a single canal (taurodontism), hypotrichosis, full upper lip without a cupid's bow, thickened and wide philtrum, and occasional juvenile glaucoma. It was described by James L. Ackerman, A. Leon Ackerman, and A. Bernard Ackerman. It can also refer to interstitial granulomatous. Noonan syndrome is a genetic condition that affects many areas of the body. People with Noonan syndrome often have some of the following features: Facial features (most obvious in babies and children and more subtle in adults): A deep groove in the philtrum (the area between the nose and mouth) Widely-spaced eyes that are vivid blue or blue. Fryns syndrome can also affect the development of the brain, cardiovascular system, gastrointestinal system, kidneys, and genitalia. Most people with Fryns syndrome die before birth or in early infancy from pulmonary hypoplasia caused by a congenital diaphragmatic hernia. However, a few affected individuals have lived into childhood

The tap causes the dent called philtrum. Thus, the newborn baby partially forgets the Torah (Hebrew for teach). This myth has been made popular by some movies too Alcohol can cause problems for the developing baby throughout pregnancy, including before a woman knows she is pregnant. Drinking alcohol in the first three months of pregnancy can cause the baby to have abnormal facial features. Growth and central nervous system problems (e.g., low birthweight, behavioral problems) can occur from drinking. According to folklore, a wide philtrum issupposedly indicative of sexual desire. But sight is far inferior to touch in identifying the philtrum.Depending on whose philtrum is being touched, you. Korolenkova MV, Starikova NV, Udalova NV Eur Arch Paediatr Dent 2019 Apr;20(2):105-111. Epub 2018 Dec 3 doi: 10.1007/s40368-018-0397-x. PMID: 3051127

1 in 30,000. CLINICAL DIAGNOSIS, but can test for above mutation. Feats (FOB): FACE: microcephaly, synophrys, long eye lashes, long philtrum, low-set ears, short upturned nose, thin downturned lips. OTHER: developmental delay (severe speech delay + mild-moderate MR), seizures (23%), congenital heart disease (VSD/ASD in 25%), GORD (90%. Nevus simplex is a vascular birthmark that occurs in 33 percent of newborns. 8 Commonly known as stork bites, angel kisses, or salmon patches, these flat, salmon-colored lesions. If your child has a deep cut, puncture, or continuous bleeding, then a doctor or ER visit might be required. As always, if you have any other questions or concerns about your child's dental health, we welcome you to give us a call! Creve Coeur Office - 314-567-1122 St. Charles Office - 636-946-5225. Tags The philtrum was the angel's very personal way of leaving a message behind. When you seek the truth and feel like the search may be a lost cause, just run your finger over your lips, close your mouth and feel the impression that was made on you Noonan syndrome is a condition that affects many areas of the body. It is characterized by mildly unusual facial features, short stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms. People with Noonan syndrome have distinctive facial features such as a deep groove in the area between the nose and.

Experts reveal which pout men deem the most attractive (and the Duchess of Cambridge doesn't fare too well) Taylor's peaked 'cupid's pout' is the mouth women most want to copy. Expert has revealed. A deep or long philtrum is one that is more depressed or longer than normal. The average philtrum length may vary between males and females, with an average length of between 11 and 15 mm. Anything longer than 13mm in a female, and 15mm in a male would be considered longer than the average A good chin is broad (horizontal length), long (veritical length) and not retruded (sagital length). Vertical length: The chin shouldnt be vertical too short and have at least an averange length. The chin also must be at least as twice as long as the philtrum. This is the most important part when it comes to the vertical chin length

Nancy B. Spinner, Beverly S Emanuel, in Emery and Rimoin's Principles and Practice of Medical Genetics, 2013. 45.4.1.1 Clinical Presentation. Affected individuals have a characteristic facies consisting of midface hypoplasia, frontal bossing, deep set eyes, long philtrum, and pointed chin.Late closure of anterior fontanel, structural brain malformations including ventriculomegaly, cardiac. Pacifica Sun + Skincare Mineral Face Shade Lotion, Coconut Probiotic, SPF 30. Badger Clear Sport Kids Sunscreen Cream, Tangerine & Vanilla, SPF 40. Avasol Mineral Sunscreen Surfer's Barrier Stick, Light, SPF 30. Sonrei Sea Clearly Sunscreen Gel, SPF 30. Banana Boat Simply Protect Baby Sunscreen Stick, SPF 50+ ANA ZAMBRANA. This is what autism looks like in our home. This is Lucas, and he's 7. He was diagnosed in December 2016. He's considered high-functioning autistic. We took this photo to share his diagnosis with family and friends on Facebook. He is the light of our lives His deep philtrum. His thicc plush plump lips. His thicc eyebrows. His thicc hair. His smol teeth. His lil squishy nose. His dimples Baby boy smile. Check for deep tendon reflexes and other primitive reflexes such as the tonic neck and moro reflex. (1) Specifically, when assessing tone, there are three tests that should be done when possible (i.e. if baby is well enough, not intubated) (7): 1) Horizontal suspension - support the baby with one hand on the chest. Normally

Christmas Day Special Indian Nose Ring Indian Nose Hoop Wedding Nose Stud Faux Nose Stud Philtrum Jewelry 16g Nose Piercing Medusa Nose Pin. From Canada Good Luck Mom and Baby Elephant Pendant 925 Sterling Silver, Handmade Repurpose Antique Vintage Red Enamel Flower Pendant & Cord Necklace Silver Gold Tones Satin Cord OOAK Refashion Eco Boho Statement Rooting Touching baby's cheek causes head to turn toward the side touched. Present in utero at 24 weeks; disappears 3-4 months; may persist in sleep 9-12 months Sucking Touching lips or placing something in baby's mouth causes baby to draw liquid into mouth by creating vacuum with lips, cheeks, and tongue

My husband has a philtrum and our daughter kind of does

Treatment. Several wrinkle treatment options are available to help smooth wrinkles or make them less noticeable. Medications. Topical retinoids. Prescription medicine that contains retinoids, which is derived from vitamin A, may reduce fine wrinkles, splotches and roughness when applied to the skin 3. Smile and reposition your fingers as necessary. Gradually ease your expression into a wide grin, keeping your fingers fixed to the same spots on your face. Your smile should be wide and open-mouthed, as natural dimples generally appear when someone has a fairly wide smile • Lips: Flat philtrum, thin vermilion border of the upper lip, and long upper lip with prominent philtrum. • Palate: high (narrow) palate, submucous cleft palate, cleft palate, cleft uvula, and big adenoid and tonsils. Submucous cleft palate is common and early detection is recommended strongly for prophylaxis of middle ear infections Remove your baby gently from the breast if he doesn't latch on correctly, then stroke the groove between the nose and upper lip (the philtrum) with your nipple. The baby will reflexively open his mouth wide and you can re-offer the breast in a better position Medical definition of philtrum: the vertical groove on the median line of the upper lip

Cranial Facial Abnormalities - Ear, Nose, ThroatEllah Leigh: Hemangioma

My baby is almost 4 months old and I notice she really

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Is it autism? Facial features that show disorder - CBS New

Distinctive facial features in some people with CDKL5 deficiency disorder include a high and broad forehead, large and deep-set eyes, a well-defined space between the nose and upper lip (philtrum), full lips, widely spaced teeth, and a high roof of the mouth (palate). Other physical differences can also occur, such as an unusually small head. Micrognathia Infant Pictures. Figure 1.62. Another variant of the median cleft syndrome ( holoprosencephaly) is cebocephaly in which there is a small nose with a single nostril above or below the eyes. Note the single orifice and aplasia of the nasal septum and philtrum. Figure 1.63 Lip Lacerations, Part II. In Part I, we discussed some of the steps in evaluation and preparation of a lip laceration to optimize repair. Here in Part II, we'll get in to the nitty-gritty of performing a repair. All of the key points in this post are discussed in this 3 minute video, detailing a repair in an ED patient: Video Player is loading Funny baby boy with varicella Stock Photos by ideallistopad 1 / 18 Dog bite on leg - wound Stock Image by sarah2 3 / 331 Closeup dog sick leprosy skin problem with white background Stock Images by mraoraor 1 / 34 Chicken pox Stock Photography by abdone 18 / 8,430 Asian senior woman patient show her scars

Other physical features seen in Down syndrome include a single crease across the palms of their hands as well as short stubby fingers with a fifth finger or pinky that curves inward (this is called clinodactyly). They often have straight hair that is fine and thin. In general, people with Down syndrome tend to be short in stature with short limbs Figure 3.3. Close-up of the face of the same infant shows the short nose, absence of the philtrum, and thin vermilion border of the upper lip. Many other findings in fetal alcohol syndrome have been reported, including epican-thic folds, ptosis, hypoplastic maxilla, deep or accentuated palmar creases, and clinodactyly. Figure 3.4

2. They have nearly 360 degree vision. Here's looking at you, kid. Wikimedia Commons. Pablo Dodda via Wikimedia Commons. Sheep have rectangular pupils that give them amazing peripheral vision - it's estimated their field of vision is between 270 and 320 degrees; humans average about 155 degrees - and depth perception Microcephaly was reported in 95% of patients, and all patients had straight eyebrows, deep-set eyes, midface hypoplasia, broad nasal root/bridge, long philtrum, and pointed chin. Other dysmorphic features included microbrachycephaly (65%), epicanthus (50%), large late-closing anterior fontanel (77%), and posteriorly rotated low-set abnormal. Take a moist washcloth and place it in the microwave until it's warm, but not burning hot. Microwaving time will vary depending on your machine, so start with 30 seconds and add 15 seconds at a time. The washcloth should be hot, but tolerable. Place the cloth across your nose and allow to sit until the heat is gone Cuts of the tongue or inside of the cheeks are the most common mouth injury. Usually, due to accidentally biting them during eating. Bites of the tongue rarely need sutures. Even if they gape open a little, the cuts usually heal quickly. If the edges come together when the tongue is still, it needs no treatment. Upper Lip Lump 911: When to see a doctor fast. There's no easy way to tell if a lump is cancerous from the outside, but there are some red flags, Dr. Shivadas says. If you experience any of the following.

Other procedures, such as deep cleaning or dental surgery, may be required. Impacted teeth are typically removed by an oral surgeon. A tooth that is cracked or damaged may require a root canal if the nerve has died or been damaged beyond repair. Pulpitis and dental abscesses may also be treated this way. In some instances, a tooth extraction. Hemosiderin staining is a permanent, or semi-permanent, bruise-like mark that can vary dramatically in size, shape, and location on the body. It typically occurs around superficial veins, close to the surface of the skin, says Dr. Aaron Shiloh of Shiloh Vein and Aesthetics, located just outside of Philadelphia.Staining is represented by a brownish discoloration either in the vein or. Okay, let's face it, all these beautiful ladies were blessed with perfect visuals and are the epitome of PERFECTION. They've all got stunning side profiles, but I.

Deep philtrum baby - dlil

It is characterized by mildly unusual facial features, short stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms.People with Noonan syndrome have distinctive facial features such as a deep groove in the area between the nose and mouth (philtrum), widely spaced eyes that are usually pale blue or. Known as America's Holistic Plastic Surgeon®, Anthony Youn, M.D. F.A.C.S is a nationally-recognized, board-certified plastic surgeon. His goal is to help health conscious men and women look and. An upper lip lift, also known as upper lip shortening, is a procedure with a high rate of patient satisfaction that is targeted to people who are unhappy with the length of their upper lip area. 1 The goal of this procedure is to shorten the upper lip and contour the vermillion, or the border where the lip meets the facial skin. San Diego Lip Lift Specialist Dr. John Hilinski is a Board. Doctor Sleep is a 2013 horror novel by American writer Stephen King and the sequel to his 1977 novel The Shining.The book reached the first position on The New York Times Best Seller list for print and ebook fiction (combined), hardcover fiction, and ebook fiction. Doctor Sleep won the 2013 Bram Stoker Award for Best Novel.. The novel was adapted into a film of the same name, which was. Amazon.com : Facial Flex Facial Exercise and Neck Toning Kit Facial Flex Device, Facial Flex Bands 8 oz & 6 oz Packs & Carrying Case - FDA-Registered Exercise Devices for Face Lift Toning & Strengthening : Facial Treatment Products : Beaut

Your Philtrum-the Sexiest Part of the Body - HubPage

If water-resistant sunscreen is clogging your pores, your skin will really benefit from a deep pore-cleansing mask. You'll want to find one that contains salicylic acid . This ingredient is a BHA (beta hydroxy acid) and since it's oil-soluble, it can penetrate into the pore lining to clear trapped debris that can lead to bumps and breakouts 1. That pimple might actually be a cyst. Underground pimples that swell up and never come to a head ( these suckers are known as cysts) are notorious for showing up in the same exact spot, says Dr. * (ASTRO) Cha Eun-Woo's aegyo sal (and perfect face by the way) * (BTS) Taehyung's asymetric eyelids (a monolid and a double eyelid, this man is special until the end) * (ASTRO) Rocky's cheekbones (this guy is a werewolf) * (ENHYPEN) Heeseung's s..

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• A medusa piercing, which is also known as a philtrum piercing is centered above the cupid's bow, between the middle of the upper lip and the bottom of the nose called the philtrum region. This piercing is typically done with a labret stud, with the ball sitting on the outside, visible above the cupid's bow of the lip Introducing Olay Smooth Finish Facial Hair Removal Duo, a specially formulated two-step system designed to gently yet effectively remove fine to medium unwanted facial hair on the upper lip and jaw line, while minimizing irritatio Laceration, tearing of the skin that results in an irregular wound. Lacerations may be caused by injury with a sharp object or by impact injury from a blunt object or force. They may occur anywhere on the body. In most cases, tissue injury is minimal, and infections are uncommon. However, sever 18 (46 cm.) Bisque socket head with plump face, deep blue glass paperweight inset eyes, thick dark eyeliner, dark painted lashes, rose-blushed eye shadow, brush-stroked and feathered brows, accented eye corners, shaded nostrils of rounded-tip nose, closed mouth, tiny tongue tip betwen outlined and shaded lips, pierced ears, brunette human hand-tied wig, French hollowed wood loose-ball-jointed. There is a broad nasal bridge with deep set eyes and blepharophimosis. The nose is small with hypoplastic alae nasi and a long philtrum. Note the H-shaped cutaneous dimpling on the chin and there may be a high palate and small tongue. These infants may have failure to thrive due to swallowing difficulties, but intelligence is in the normal range Juvederm Ultra and Ultra Plus: While you may have received one of these fillers in your lips or cheeks, Juvederm Ultra and Juvederm Ultra Plus are primarily indicated for the treatment of nasolabial folds and marionette lines. Juvederm Ultra is designed for mild-to-moderate lines and wrinkles; Ultra Plus is for deeper wrinkles and folds